Biomarkers for Drug Effectiveness
Micromedic Technologies Ltd. has found two successes in a preliminary trial together with the University of Florida for the development of innovative biomarkers for pharmacogentics, the improvement of drug effectiveness. The trial tested 47 patients with multiple myeloma receiving Aredia and Zometa.
The trial objective was to test whether the use of Micromedic's genetic biomarker could predict which patients will develop side effects from the drugs; namely significant deterioration in bones of the mouth. Currently, 13% of multiple myeloma patients receiving these two drugs develop this side effect.
Professor Joseph Katz, Director of the University of Florida's College of Dentistry, Department of Oral Diagnostic Science oversaw the trial. Micromedic's genetic biomarker found a group of patients that were 11.6 times more likely to develop the side effects, compared with the control group. Micromedic's goal is for its test to be conducted on every patient who is a candidate for the drugs, so that patients who are predicted to develop the side effect can be given alternative treatment or be given treatments in advance to prevent the side effect.
Micromedic will now conduct a further trial to confirm the findings.
The trial objective was to test whether the use of Micromedic's genetic biomarker could predict which patients will develop side effects from the drugs; namely significant deterioration in bones of the mouth. Currently, 13% of multiple myeloma patients receiving these two drugs develop this side effect.
Professor Joseph Katz, Director of the University of Florida's College of Dentistry, Department of Oral Diagnostic Science oversaw the trial. Micromedic's genetic biomarker found a group of patients that were 11.6 times more likely to develop the side effects, compared with the control group. Micromedic's goal is for its test to be conducted on every patient who is a candidate for the drugs, so that patients who are predicted to develop the side effect can be given alternative treatment or be given treatments in advance to prevent the side effect.
Micromedic will now conduct a further trial to confirm the findings.
posted by gwg at 3:41 PM
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